HEIRS TO THE WRATH features a roster of 16 playable characters that could be selected by the player. Each character has their own Deity transformation, moveset, personality and they are all part of the game story.

A fighter, or an Heir, is a human with the ability to transform himself into a deity form giving him divine power in relation with his transformation. For example, as the Heir of Helios, Titan of the sun, Alec uses his power from the sun and can fight with a fire whip.

Depending on their story, a fighter is, sometimes, related whether to The Primordial Program, an intergovernmental operation fighting against the Wilting or to The Eighth Seal, a secret cult fighting for the Wilting.